Whole Body Magnetic Resonance Imaging (WB-MRI)is a radiation-free imaging technique that is becoming increasingly important in the diagnosis of soft tissue tumors, especially for screening metastases, as well as for monitoring primary tumors and metastatic lesions in patients post-treatment and also for tracking individuals with a known risk of malignant transformation, such as those with neurofibromatosis and other genetic disorders. This imaging technique is continuously advancing with the new multichannel receiver coil technology, the fast-imaging sequences with parallel imaging, simultaneous multi-slice, compressed sensing, and the moving table. A significant advantage of this technique is that it enables the acquisition of both relevant morphological and functional information during a single examination. The majority of patients can tolerate this procedure without any issues. However, sedation may be necessary for pediatric patients, which can be advantageous as it allows for imaging of both the primary tumor location and any metastases during the same sedation session. Proper use and interpretation of the WB-MRI images require a thorough understanding of both its advantages and limitations. WB-MRI is currently the subject of ongoing research and continuous advancement with improvements. Experienced radiologists in oncological imaging utilizing advanced MRI technology are likely to enhance the efficacy and adoption of WB-MRI.