The pharmaceutical industry is challenged by issues of transparency, traceability, and integrity within its global supply chain. Traditional methods have often been inadequate in addressing these concerns, which are crucial for maintaining ethical standards and ensuring consumer trust. This paper proposes a novel system utilizing blockchain technology, smart contracts, encrypted Non-Fungible Tokens (NFTs), and the InterPlanetary File System (IPFS) to enhance the management of pharmaceutical supply chains. By incorporating these technologies, our framework seeks to improve transparency and data integrity from the source to the consumer. We also evaluate the application of six encryption algorithms—RSA, RC4, DES, ChaCha20, Blowfish, and AES-to determine the best balance between security and efficiency. This system has been tested on four EVM-compatible platforms: Binance Smart Chain, Polygon, Fantom, and Celo, assessing its adaptability and operational efficiency. The results indicate that our approach not only meets the stringent requirements of the pharmaceutical sector but also establishes a reliable, transparent, and equitable supply chain system.