Men in Southeast Asia experience shorter life expectancies compared to women, influenced by a combination of biological, behavioral, and socioeconomic factors. This chapter examines the reasons behind this disparity, highlighting key issues such as genetic and hormonal differences, risk-taking behaviors, reluctance to seek medical help, and higher prevalence of noncommunicable diseases (NCDs) like cardiovascular diseases and cancer. Communicable diseases, occupational hazards, and socioeconomic barriers further exacerbate male health risks. Specific malignancies such as lung, liver, and oral cancers are more common in men due to lifestyle factors like smoking and alcohol consumption. Additionally, men face unique challenges in accessing healthcare, including economic barriers, lower health literacy, and cultural norms that discourage medical consultations. Guidelines for medical professionals emphasize the importance of promoting preventive health measures, addressing behavioral risks, enhancing healthcare access, improving mental health services, and fostering positive health-seeking behaviors. By implementing targeted interventions and culturally sensitive health education, healthcare providers can help improve health outcomes and life expectancy for men in Southeast Asia.