Long-term survival rates in children with cancer have been improved to more than 80%, which were lower than 20% in the 1960s. However, the survival rates are still only about 20–30% for children with cancer in many low- and middle-income countries (LMIC) where most of the 400,000 children who develop cancer annually live. To make a significant and sustainable impact on cancer care, all stakeholders in childhood cancer care should be aware of the current polices, decisions, and strategies from global organizations including the United Nations (UN), World Health Organization (WHO), major organizations, and other leading groups. This chapter provides an overview to the readers on the major global and national policies and regulations and impact on the childhood cancer care. This is particularly relevant in the present context with a worldwide push by the WHO Global Initiative and action at regional and national levels.