Supersymmetry (SUSY) remains one of the most appealing theories beyond the standard model (BSM) of elementary particles, due to its completeness, rich phenomenology, and ability to provide answers to fundamental open questions of modern particle physics and cosmology. The sample of proton-proton collisions at 13 TeV center-of-mass energy collected with the Compact Muon Solenoid (CMS) detector during Run II of the CERN Large Hadron Collider (LHC) is a statistically powerful data set to look for new SUSY signatures and extend previous searches into unexplored regions of the parameter space. A number of recent results from SUSY searches with the full CMS Run II data set are presented in this contribution.