Over the past decade, postgrowth/degrowth debates have seen an increasing uptake in research on regional (economic) development. Against this backdrop, this contribution aims at discussing their ontological, conceptual, and methodological implications for economic geography and beyond. It first situates growth-criticism in the broader context of social and spatial inequalities, food crises, climate change, and environmental justice, before assessing its potential ramifications on prevailing theories, models, and methodological perspectives. Taking two key concepts as illustrative examples (Regional Innovation Systems—RIS, and Global Production Networks—GPN), it examines how economic geography implicitly adheres to prevailing growth imperatives. Introducing the notions of the Foundational Economy as well as the Economy for the Common Good, the article finally discusses how economic geography can conceptually engage with the challenges of a socio-ecological transition and the prospects of a postgrowth-oriented future.