This chapter explores the Nyāya school’s rigorous and systematic engagement with Adhyātma, or the pursuit of ultimate reality ( yathārtha vastu) and self-realization ( Ātma-jñāna or Ātma-sākṣātkāra), as an integral component of Indian philosophical inquiry. Through an analysis of the Nyāya conception of the self ( ātman) and its relation to supreme self ( Paramātma), the discussion highlights Nyāya’s unique epistemological and metaphysical framework in addressing the fundamental questions of existence, consciousness, and liberation ( mokṣa). Central to this Nyāya’s approach is the concept of valid means of knowledge ( pramāṇas), which illuminate the nature of the self and its relationship to karmic forces ( Adṛṣṭa), ultimately governed by a conscious supreme being. By investigating Nyāya’s categories of reality ( padārthas), this chapter demonstrates how logical reasoning and scriptural authority converge to articulate a path to liberation. The chapter also situates Nyāya’s teachings within the broader spiritual landscape of Indian philosophy, contrasting its emphasis on rational inquiry with both the devotional ( Seśvara Adhyātma) and self-reliant ( Nirīśvara Adhyātma) traditions. By integrating metaphysical analysis with practical spiritual guidance, Nyāya philosophy emerges as a vital contribution to the discourse on self-realization and the attainment of ultimate freedom. This inquiry bridges the gap between theoretical rigor and spiritual praxis in spirituality discipline, offering insights into the perennial quest for transcendence and the nature of ultimate reality.