Age-related macular degeneration (AMD) is characterised by the dysfunction of the retinal pigment epithelium (RPE), deposition of drusen and degeneration of the overlying photoreceptors, leading to the loss of central vision. AMD is a complex and multifactorial disease, with the greatest risk factor being age. As we age, changes occur to our immune system, a phenomenon known as inflammageing. There is mounting evidence indicating a role for the immune system in the development, progression, pathology and potentially, treatment of AMD. However, the specific contribution played by immune cells remains unclear. This chapter discusses evidence implicating a role for the circulating macrophages in AMD.