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Sero-epidemiology uses measures of antibodies against a pathogen within a population to understand the transmission and epidemiology of infectious diseases. As antibodies persist for longer in the immune system than pathogens, serology offers an insight into exposure over a wider time frame than traditional diagnostics which capture active infections. This is useful as it allows for the reconstruction of transmission history from a representative cross-sectional survey over a period of time. This chapter outlines the core concepts of sero-epidemiology and its applications, with a focus on malaria. The principles in serological methods and study design, molecular, epidemiological and statistical considerations, and the limitations of sero-epidemiology as a tool are discussed, with examples of real-world applications.

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Sero-epidemiology: The Use of Population-Based Antibody Measures to Inform Disease Dynamics

  • 章节

  • 发表日期：

    2025年

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  • Isabel Byrne,
  • Lindsey Wu,
  • Chris Drakeley

摘要

Sero-epidemiology uses measures of antibodies against a pathogen within a population to understand the transmission and epidemiology of infectious diseases. As antibodies persist for longer in the immune system than pathogens, serology offers an insight into exposure over a wider time frame than traditional diagnostics which capture active infections. This is useful as it allows for the reconstruction of transmission history from a representative cross-sectional survey over a period of time. This chapter outlines the core concepts of sero-epidemiology and its applications, with a focus on malaria. The principles in serological methods and study design, molecular, epidemiological and statistical considerations, and the limitations of sero-epidemiology as a tool are discussed, with examples of real-world applications.