DiGeorge Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome or velocardiofacial syndrome, is a genetic disorder caused by the deletion of a small piece of chromosome 22. This chapter provides an overview of the neurodevelopmental disorder, including its epidemiology, underlying genetic and neurobiological mechanisms, common clinical features, psychiatric comorbidities, assessment methods, psychosocial and biological treatments, and medical comorbidities.