Mesotherapy Background, Mechanisms, Techniques and Classification

Mesotherapy is a noninvasive cosmetic and medical process that involves several microinjections of bioactive chemicals, medicines, and vitamins into the middle layer of the skin. This approach, which is based on ancient techniques and was updated in the mid-twentieth century, seeks to address a variety of local medical and cosmetic conditions, including skin aging, wrinkling, and hair loss. The injected fluids remain under the skin longer than deeper injections do, which increases their effectiveness. The key benefit of mesotherapy is the localized, slow release of drugs, which results in lower drug doses and less invasiveness. The method uses phosphatidylcholine and deoxycholic acid to mobilize fat and other substances, rejuvenating the skin. Various approaches, such as intraepidermal, nappage, and point-by-point approaches, are used depending on the needle depth and injection strategy. Despite its extensive usage, notably in Europe and South America, the precise processes and long-term consequences of mesotherapy are unknown, and it lacks FDA clearance for some uses. Additional clinical trials are needed to confirm its safety and effectiveness.