Globally, annual bone fractures are estimated to be 3% among women and 4.5% among men. Treating those fractures imposes a huge burden on healthcare systems since several hospital visits and hospitalizations might be needed in cases of surgical processes involved in the treatment protocol. Generally, fractures in the lower and upper extremities of bones are more frequent, followed by the legs, arms, trunk, and lastly, the skull and head. In many cases, to treat a fracture, orthopedic cortical screws are required, however, depending on the site of the fracture, fabricating the screw to facilitate healing might be challenging. Herein, the emergence of 3D printing offers promises to produce patient-specific bone implants/screws, however, failures in 3D-printed cortical screws due to excessive loads were a concern to researchers. Thus, this work studies the 3D-printed PolyLactic Acid (PLA) cortical screws coated with various nanoparticles and their effect on mechanical qualities. A set of samples was 3D-printed using fused deposition molding (FDM), and then some of them were coated with one of the following: aluminum oxide nanoparticles, hydroxyapatite nanoparticles, and titanium oxide nanoparticles. The results show that the coating material used has a substantial impact on the tensile strength of PLA screws. The highest mechanical performance is demonstrated by a two-layer titanium covering. These findings offer suggestions for improving coating techniques to improve the strength qualities of PLA-based components utilized in orthopedic applications.