Antiallergic, Antioxidant, Anti-Inflammatory and Immunostimulant Potential of Kefiran Postbiotic: Molecular Docking, Prediction of Pharmacokinetic Properties and Biological Activity
摘要
Kefiran is an example of a postbiotic of kefir grains and is believed to be primarily responsible for the health-promoting effects. This study aimed to evaluate the antiallergic, antioxidant, anti-inflammatory and immunostimulant potential of the main component of kefir, in silico, through prediction of biological activity and molecular docking. The prediction of the biological activity of kefiran showed significant results for antiallergic, anti-inflammatory, antioxidant and immunostimulant activities and the docking was carried out between this compound and the following biological targets; H1R1 iNOS, PLA2 and VEGF. It is concluded that kefiran can be used properly in the development of drugs or functional foods, which results in a probable inhibitory action in the immune response and the treatment of children’s food allergies.