Use of Phytotherapeutics in the Amazon with a Focus on the Metropolitan Region of Belém: Traditional Applications and Computational Studies of Bioactive Compounds

The use of phytotherapeutics in the metropolitan region of Belém is deeply influenced by the rich Amazonian biodiversity and the vast traditional knowledge about medicinal plants. This context offers a wide range of natural and accessible therapeutic alternatives, benefiting public health and promoting environmental and economic sustainability. The appreciation of phytotherapeutics not only respects cultural traditions but also encourages responsible agricultural practices and the conservation of local biodiversity. The integration of phytotherapeutics into the public health system can bring numerous benefits, including the provision of more economical treatments with fewer side effects. To optimize the discovery and development of new bioactive compounds, computational strategies have proven to be indispensable. Tools such as molecular modeling, molecular dynamics, and molecular docking allow the virtual screening of thousands of compounds, accelerating the process of identifying potent therapeutic substances. Furthermore, cheminformatics and bioinformatics play crucial roles in organizing and analyzing large volumes of chemical and biological data, revealing important patterns and relationships that may not be detected by traditional methods. These approaches are particularly valuable in the Amazon, where the systematic exploitation of native plants still has enormous untapped potential. Therefore, the purpose of the study is to carry out a literature review, seeking to evaluate and include scientific data, combining the traditional use of phytotherapeutics with advanced computational strategies offers a promising path for innovation in medicine, promoting health and well-being while preserving the biodiversity and cultural knowledge of the Amazon.