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Moonlighting Proteins: Importance and Current Scenarios

  • Ana Carolina Franco Severo Martelli,
  • Beatriz Brambila,
  • Mariana Pegrucci Barcelos,
  • Flávia da Silva Zandonadi,
  • Solange Cristina Antão,
  • André Vessoni Alexandrino,
  • Carlos Henrique Tomich de Paula da Silva,
  • Maria Teresa Marques Novo-Mansur

摘要

This chapter investigates the current scenario of moonlighting proteins, elucidating some molecular mechanisms and structural adaptations, besides highlighting their profound impact on pathogenesis for different organisms and situations. The related databases and main forms of prediction are explored, using some characteristics observed in described moonlighting proteins and applying them to bioinformatics tools. Lastly, the potential applications of moonlighting proteins for therapeutic purposes are discussed. In conclusion, moonlighting proteins prediction, as well as their validation as targeting molecules and practice application remain as great challenges for future research and therapeutic innovation.