Smart Life (SL) systems do not exist in a technological vacuum; they are embedded in a social ecosystem and have rich and complex interactions with their surroundings. It is important to recognize that their design and implementation will have an impact on the individuals and communities around them. This chapter examines the social, behavioral, and ethical issues to be considered in a holistic systems approach to SL engineering, to help practitioners and stakeholders to design the strategies needed for successful SL deployments. It addresses these topics from several disciplinary viewpoints and provides a comprehensive set of references for those requiring further detailed information.