Genetic interventions hold immense promise as a transformative tool in addressing global hunger and advancing food security through the enhancement of fisheries. This chapter delves into the convergence of genetics, aquaculture, and food security, unraveling the potential of genetic interventions to revolutionize fisheries into a potent and sustainable source of nutrition. Through an extensive exploration of selective breeding, advanced genetic technologies, and innovative genetic engineering approaches, the chapter illuminates how genetic interventions can elevate the productivity, resilience, and nutritional value of fish populations. Drawing on case studies, ongoing research endeavors, and emerging trends, this chapter provides invaluable insights into the practical applications and implications of genetic interventions for fisheries enhancement on a global scale. Ultimately, it underscores the transformative role of genetic interventions in mitigating hunger, fostering food security, and driving sustainable development, paving the way toward a more equitable and resilient food future for all. Realizing the full potential of fish genetics and breeding programs demands concerted action from policymakers, industry stakeholders, and research communities. Through responsible innovation, collaboration, and knowledge exchange, we can leverage genetics to propel sustainable development and resilience in aquaculture, ensuring the availability of nutritious and sustainable seafood for present and future generations. By advocating for the integration of fish genetics in aquaculture development agendas, highlighting the potential of genetic innovation, and fostering collaboration and knowledge-sharing among diverse stakeholders, we can harness genetics to build a more food-secure, resilient, and sustainable future for upcoming generations.