Oral and Dental Phenotype of Ectodermal Dysplasias

The oral cavity is lined with epithelium derived from the ectoderm. The development of structures derived from this cell layer is similar to the development of extra-oral structures derived from epithelium. Tooth development is extensively studied in mammals and represents a common pattern for the development of ectodermal placodes deployed in diverse types of epithelium organogenesis, such as salivary glands, mammary glands, sweat glands, limb buds, and more [1].