Describing the transformations to human existence through examination of the experiences of pathological breathlessness uncover that the traditional biomedical models and approaches need to be supplemented to fully understand the impacts of these ways of being. Pathological breathless experiences are wide-ranging and vary with intensity across respiratory disorders, regardless of whether they are the same condition or not. The variation differs from moment to moment, day to day, with perception, past experiences, and affective states all impacting upon their perceived severity and interpretation. This, it is argued, gives weight to viewing them as changes to one’s being-in-the-world [In-der-welt-Sein], more colloquially known as “lived” or “first-person experience” via phenomenological description, rather than as a distinct symptom. This strengthens the case for viewing pathological breathlessness (clinically termed “dyspnoea”) as an umbrella term that can encompass different breathless experiences, experiences that nonetheless share some key features that warrant this approach. This means that treatment needs to be more holistic, with integrated healthcare approaches required that consider all the facets of the experience of breathlessness and its impacts instead of medical interventions for symptom relief on the one hand, and psychological interventions for comorbid anxiety on the other. This chapter gives an overview of breathlessness in philosophy, integrating insights from the medical humanities to support a phenomenological approach to illuminating these experiences.