Cultural sustainability serves as a driving force for maintaining a cultural group’s identity, practices, and beliefs to protect its values from external forces. In most Asian countries, ethnic enclaves are maximized to generate a vibrant economy rooted in tourism, whether the genesis was a product of spatial segregation or has evolved organically. There have been several historical enclaves in Manila. Among the most famous are the Chinese in Binondo and the Muslims in Quiapo. Scattered on strategic points outside the fortress city of Intramuros, the urban foothold of these enclaves can be traced as far back as the sixteenth century during the Spanish colonial era. The lack of integrative design and development in these urban ethnic enclaves, which led to diminished socio-economic potentials, sparked the motivation for this study. Creating an objective resource material will serve as a foundation for identifying, preserving, and conserving their cultural identity. Architectural manifestations encompassing the most distinct elements within the geographical bounds, in addition to the paths, nodes, edges, districts, and landmarks, were tackled to contextualize design and development parameters. The analysis also focused on identifying various urban designs and architectural elements associated with the enclave’s physical and social domains. This was achieved through archival research, site investigation, GIS mapping, and surveys via a Kobo Toolbox platform. Results of the analysis were then synthesized as a basis for designing and developing ethnic enclaves that empower the community and their descendants to remain attached to their way of life and form new connections to the city while preserving their unique attributes.