As computer technology becomes more integrated into biological science, the amount of data that needs to be tracked has been experiencing unprecedented growth. Data sources range from biological sequences to 3D structures, DNA traces, and proteomic gels. The wide range of biological databases providing essential information related to the life sciences is evident in the snapshot of a small subset of databanks available to biomedical researchers shown in Fig. 4.1. Databases have become an essential tool for biotechnology research today.