The Orchestra of Genetics: Genetic Predisposition to Metabolic Syndrome

Metabolic syndrome (MetS), due to unhealthy lifestyle has been a disturbance to the population worldwide. For this complex disease, tolerance has been observed with current therapy and also novel drug discovery is at bay. While one target- one drug is unfavorable for complex disorders, the current definition of disease also obstructs the precise treatment. Thus, the urgent need is to redefine the disease which is more based on endotypes rather than phenotypes. The new definition will expand driver genes, proteins and their disease modules. With the help of blooming field of bioinformatics, the genes, encoded proteins and associated pathways were identified for MetS using software like STRING, KEGG pathways. The network between them were created by Cytoscape. The genes with most significant interactions were reviewed as potential drug targets for MetS. With precise and effective targeting, the therapy will shift from treating symptoms to curing disease.