The Impact of Gut Hormones and the Gut-Adipose-Liver Axis in Metabolic Syndrome: An Overview of Nrf2 Involvement in the Signaling Pathways
摘要
Nuclear factor erythroidNuclear erythroid factor-2 2-related factor 2 (Nrf2) has been identified as a master regulator of the adaptive response to both endogenous and exogenous oxidative and electrophilic stressors. Emerging evidence suggests the pivotal roles of Nrf2 in the development of obesity and regulation of adipocyte differentiationAdipocyte differentiation through its interaction with other transcription factors and receptors involved in metabolic regulation. Nrf2’s crosstalk with other molecular pathways is being rigorously pursued by several investigators. This review provides an overview of the currently known information on the involvement of Nrf2's in causing obesity-induced Metabolic Syndrome (MetS) as well as the potential of different medications in targeting Nrf2 for reducing obesity and MetS under clinical settings.