Uncovering hidden patterns and relationships in knee OA data using machine learning algorithms can be incredibly useful for predicting illness progression and developing more effective treatments. By analyzing large amounts of data, machine learning algorithms can identify patterns and relationships that might not be immediately apparent to human researchers. This can help us better understand the mechanisms behind knee OA and identify potential targets for treatment. By developing more potent treatments, we may be able to slow the progression of the disease and improve patient outcomes. The knee osteoarthritis dataset information was initially acquired from Kaggle and the information on knee osteoarthritis is processed before model training. The study aims to develop and apply advanced machine learning methods, such as deep learning techniques like CNN-SVM, Mobilenet v2, Resnet152v2, Resnet 50, and EfficientnetB5, to analyze knee OA data and develop accurate prediction models for early diagnosis and prognosis. The study evaluates the performance of these models on a dataset of individuals with knee OA to determine their efficacy and accuracy.