Novel Synthesis of 1-arylnaphtho[1,2-d]isoxazole Through Oxidation of 1-amidoalkyl-2-Naphthols Using MnO2
摘要
Three-component condensation of β-naphthol, urea, and aldehyde was carried out for the synthesis of 1-amidoalkyl-2-naphthols under acidic conditions. These synthesized 1-amidoalkyl-2-naphthols on reaction with MnO2 unusually led to the synthesis of 1-arylnaphtho[1,2-d] isoxazoles. The reaction signifies efficiency of MnO2 in forming N-O bond in organic synthesis.