This entry examines the influence of artificial intelligence (AI) systems in the workplace on employee well-being. While it acknowledges the positive aspects of AI, it places a stronger emphasis on the potential negative effects that can arise in a work environment. The entry introduces a conceptual framework that outlines the antecedents and consequences of the work environment in relation to AI systems deployment. It offers insightful recommendations for future research aimed at increasing awareness among both scholars and organizations about the often-overlooked psychosocial risks and negative impacts on employees’ mental health linked to AI implementation in the workplace. Finally, this entry highlights the essential role of strategic human resource planning in AI implementation, emphasizing the need to provide employees with comprehensive training and social support.