The integration of Multiple-Input Multiple-Output (MIMO) and Orthogonal Frequency Division Multiplexing (OFDM) offers significant performance improvements by leveraging the strengths of both technologies, resulting in enhanced data throughput, coverage, and energy efficiency. Traditional modulation techniques such as QPSK, 16QAM, and 64QAM, while effective, are limited in their ability to maximize spectral efficiency and data rates, particularly in the high-Signal-to-Noise Ratio (SNR) conditions prevalent in 5G networks. This study extends the evaluation to higher-order schemes including 256QAM, 1024QAM, and 4096QAM to address these limitations. Key performance metrics analyzed include Bit Error Rate (BER), throughput, and spectral efficiency. Using MATLAB simulations, results demonstrate that higher-order modulation schemes provide superior performance in terms of throughput and spectral efficiency at higher SNRs, emphasizing their potential to enhance data rates and reliability in 5G MIMO-OFDM systems. Conversely, lower-order schemes like QPSK exhibit greater robustness in noisy environments, highlighting their continued relevance in specific scenarios where reliability is prioritized over spectral efficiency. Future research should explore the potential of hybrid modulation approaches, which combine the strengths of both low- and high-order schemes to optimize performance across varying network conditions.