Human trafficking, an egregious and multifaceted crime, is predominantly seen as an organized crime and not a human rights violation that crime-control strategies can successfully deter. The emphasis on executing a crime-control model over a human rights approach presents several challenges in how human trafficking is defined and approached by the criminal justice system. Mexico’s current anti-trafficking law, Ley General para Prevenir, Sancionar y Erradicar los Delitos en Materia de Trata de Personas y para la Protección y Asistencia a las Víctimas de estos Delitos (Ley General for short), has only been in effect since June 2012, despite the country’s decision to criminalize trafficking in persons federally in November 2007. Using an interrupted time series design and ARIMA modelling, this study used secondary data from SESNSP (Secretariado Ejecutivo del Sistema Nacional de Seguridad Pública) to assess the legal impact of Mexico’s Ley General on human trafficking investigations at the federal level between 2007 and 2019 across two states, Chiapas and Puebla, and the country’s capital, Mexico City. The results suggested that Ley General did not have a statistically significant impact on initiating human trafficking investigations in these areas. A discussion of alternative explanations that influence human trafficking response in Mexico is provided.