The number of COVID-19 fatalities in Europe is significantly higher than in Africa. This, among other factors, has reignited the optimism of many Africans about opportunities to migrate to Europe in search of greener pastures. Many people migrate legally or illegally for a variety of reasons. Human traffickers frequently target the most vulnerable people, particularly women and girls, promising them a brighter future while exploiting them. Sex labour is a developing phenomenon; it has been modernised and taken on new dimensions, particularly after the emergence of COVID-19, which has had a devastating impact on Africa’s economy and driven everyone to go virtual. Human trafficking and modernised prostitution can be both internal and external; this global criminal industry is led by multinational criminal organisations that span continents. This study investigates the unholy union of human trafficking and modernised prostitution in Nigeria in the post-COVID-19 age, as well as its implications for the position of African women within and outside of the family setting. Secondary data from journals, publications, and other published material was used in the paper. African societies should look within, integrating indigenous cultural elements with modern techniques in combating human trafficking and the expansion of modern prostitution to improve the status and dignity of African women and their capacity for development.