An original serious game prototype named ‘Puzzlegram’ is created for the elderly demographic in group settings as the target players. Puzzlegram is precisely designed to accentuate memory, auditory interaction as well as haptic response to visual signals with the use of music. Music is introduced as a key component for establishing the game design that provides a source of meaningful contextualization—familiar music from the past—for setting the game mechanics, which facilitated the construction of the serious game design process. The discussion topics raised include the need to design serious games for fostering meaningful interactions, as well as developing a thorough framework for constructing purposeful design for serious games. A potential integral of artificial intelligence to Puzzlegram may involve assigning a novel dimension to its existing problem-solving task by adapting to varying states of cognitive function for monitoring purposes based on an individual’s interaction with the game.