New Antiarrhythmic Drugs and New Targets for Antiarrhythmic Drugs

The growing burden of cardiac arrhythmias in combination with the suboptimal efficacy and safety of current therapeutic modalities for arrhythmia management highlights the need for developing more efficacious and safer treatment options. Antiarrhythmic drugs (AADs) continue to play a crucial role in the treatment of cardiac arrhythmias. Although there has been a paucity of new AADs, significant progress has been made in the understanding of arrhythmia mechanisms, giving rise to novel potential targets and indications for AAD treatment. Recent results obtained with novel AADs and the discovery of new drug targets are promising, while developments in repurposing and reformulating already approved drugs for novel therapeutic indications, are being explored as potential faster routes to clinical application of new therapeutic approaches. This chapter reviews the most promising novel AAD targets and compounds currently under development.