Open defecation (OD) is prevalent in most rural communities in Ghana. Eight (8) out of the 16 regions practice it. In view of this, the Government of Ghana in 2006 adopted Community-Led Total Sanitation (CLTS) as a sanitation intervention to end OD in rural communities. CLTS is a community participatory approach that addresses OD by helping community members to reach a collective demand for a behavioural change towards sanitation. Since the adoption of CLTS, reports indicate that its implementation is carried out by Non-Governmental Organisations (NGO). The study seeks to determine the factors contributing to the sustainability of the CLTS programme by NGOs. Through semi-structured interviews, primary data were collected across eight regions from sanitation specialists, consultants, coordinators, environmental health officers, and field facilitators. The results show that sustainability of the CLTS by the communities is based on factors such as the establishment of by-laws, fines, and sanctions, league tables, pride of a community being open defecation free (ODF), improved latrine technologies, follow-ups, and similar initiatives. However, to obtain more sustained ODF communities, the government of Ghana should intensify the use of National League Tables where districts and communities on top of the table will be rewarded and showcased. The government should consider making funds available for follow-ups after ODF certification.