With the unraveling of the mechanism for CRISPR-Cas systems in Streptococcus pyogenes in 2012, the application of the basic knowledge to gene editing revolutionized life science research. The newest gene technology method brings with it the promise of new cures for genetic diseases, bringing us ever closer to truly personalized medicine. It’s a fascinating and potentially controversial topic that will capture the interest of your high school students. Fortunately, there are now plenty of CRISPR-related resources available, including wet-labs that allow students to actually perform CRISPR gene editing in the classroom. Many (perhaps most) high school budgets, however, may not be in a position to purchase and implement expensive lab kits. To meet this need, there are also a variety of free and inexpensive resources to introduce CRISPR in the classroom. The goal of this chapter is to introduce you to CRISPR (also called CRISPR-Cas9) and direct you to some resources for teaching CRISPR to your high school students.