The Rural-Urban Nutrient Partnership (RUN) project offers a solution to close the nutrient cycle in a German urban settlement by introducing an innovative technical and social approach. The technical concept of RUN considers the recovery of nutrients and biopolymers from a mixture of blackwater and kitchen waste through the development and combined application of technologies, such as struvite chemical precipitation, usage of natural zeolites for the sorption of nitrogen and potassium, biopolymer, and biochar production. The selection and operational principles of these technologies are described and discussed in this chapter. In addition, the non-technical concept as part of the societal approach is also comprehensively discussed, including the real laboratory and experience space. Moreover, a sustainability assessment of this project will be conducted to evaluate the concept holistically. The indicator-based sustainability assessment, called the Integrative Concept of Sustainable Development (ICoS), was chosen in this purpose. The proposed indicators that represent the sustainability in RUN are also included. Finally, this sub-chapter is expected to provide insights into the sustainable use of wastewater treatment and nutrient recovery technologies from a research perspective. It can also be seen as an innovative solution to address the sustainability challenges that countries in the world face, including Chile.