Aiming to promote key EU interests of good governance, democracy, rule of law, and human rights, the European Neighbourhood Policy (ENP) relies on many more actors than the EU’s authorities (e.g. neighbourhood countries’ authorities, people, or domestic civil society organisations as main stakeholders, other interested or neighbour countries) and naturally depends on a number of factors of influence, specifically acting in different systems (as the design of an administrative system of the involved countries, their domestic governance practices, international relations, geo-political context, various crises, historical values, a particular path of development, legislative framework or political regime, etc.). Assuming that the strongest triggers of the domestic reforms targeting the ENP policy objectives are internal rather than external, and the sustainability of the reforms depends mostly on internal factors, our aim is to synthesise the main lessons and best practices that could have a highly normative relevance for EU’s and neighbourhood countries authorities’ policy making, based on the comparative study of the public administration and governance in the EU’s Eastern Neighbourhood countries and the particular reforms that have been implemented during recent years, in times of crises. The value of this chapter rests with the comparative approach and proposed recommendations, useful both for EU’s institutions and national authorities of analysed countries in order to strengthen their partnerships, regulatory frameworks, and public policies.