Survival analysis is paramount for cancer patients as it offers crucial prognostic insights for treatment planning. The performance of existing survival analysis methods is mainly limited by two factors: 1) inefficient extraction of features from multi-modal medical data, e.g., MR images and clinical diagnostic descriptions; and 2) inadequate focus on disease-relevant regions, e.g., primary tumor. To deal with these challenges, in this study, we propose a rectal cancer survival analysis model, dubbed as SurRecNet, which effectively fuse MR images and diagnostic descriptions and takes advantage of multi-task learning. Specifically, we introduce a cross-modality alignment module, aiming to precisely align diagnostic descriptions with MR images at a granular level and facilitate accurate survival analysis. Furthermore, SurRecNet simultaneously predicts tumor masks, relapse states, and survival outcomes by leveraging multi-task learning strategy, imitating the diagnostic process of radiologists to enhance prediction performance. Experimental results on a real clinical rectal multi-modal dataset demonstrate that our SurRecNet significantly outperforms the state-of-the-art methods.

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SurRecNet: A Multi-task Model with Integrating MRI and Diagnostic Descriptions for Rectal Cancer Survival Analysis

  • Runqi Meng,
  • Zonglin Liu,
  • Yiqun Sun,
  • Dengqiang Jia,
  • Lin Teng,
  • Qiong Ma,
  • Tong Tong,
  • Kaicong Sun,
  • Dinggang Shen

摘要

Survival analysis is paramount for cancer patients as it offers crucial prognostic insights for treatment planning. The performance of existing survival analysis methods is mainly limited by two factors: 1) inefficient extraction of features from multi-modal medical data, e.g., MR images and clinical diagnostic descriptions; and 2) inadequate focus on disease-relevant regions, e.g., primary tumor. To deal with these challenges, in this study, we propose a rectal cancer survival analysis model, dubbed as SurRecNet, which effectively fuse MR images and diagnostic descriptions and takes advantage of multi-task learning. Specifically, we introduce a cross-modality alignment module, aiming to precisely align diagnostic descriptions with MR images at a granular level and facilitate accurate survival analysis. Furthermore, SurRecNet simultaneously predicts tumor masks, relapse states, and survival outcomes by leveraging multi-task learning strategy, imitating the diagnostic process of radiologists to enhance prediction performance. Experimental results on a real clinical rectal multi-modal dataset demonstrate that our SurRecNet significantly outperforms the state-of-the-art methods.