Calcium signaling controls and manages calcium activities such as the initialization of calcium, sequestration and extrusion, calcium-binding proteins, homeostasis, and the majority of cellular pathways. Calcium signals and signaling pathways are activated through intracellular, extracellular, and coordinated activity of intracellular and extracellular components of calcium families. This cellular phenomenon is supervised by the temporal and spatial concentration levels of calcium ions. The overstimulation and dysfunction in spatiotemporal activity trigger various diseases of the nervous system and neurocognition state. To date, the precise cause of neurocognition is poorly known, and thus, understanding the role of calcium signaling that can be transferred from a cellular mechanism into a neurocognition state is important for controlling and managing disease levels.