Scholarlink

Mental health problems are known to arise from the intricate interplay between an individual’s genetic profile and environmental influences. Functional genomics involves the integration of multiple approaches to identify the mechanisms regulating gene expression and can improve the detection of vulnerable individuals to the effects of early adversity exposure. This chapter revisits the concept of functional genomics and explores innovative techniques across different levels of gene regulation. The application of these functional genomics tools to improve polygenic risk score predictions and detect gene-environment interactions in the psychiatric field is discussed.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Using Functional Genomics in the Understanding of Gene-Environment Interaction Effects on Mental Health

  • 工具书词条

  • 发表日期：

    2025年

查看全文
  • Patricia Maidana Miguel,
  • Patricia Pelufo Silveira

摘要

Mental health problems are known to arise from the intricate interplay between an individual’s genetic profile and environmental influences. Functional genomics involves the integration of multiple approaches to identify the mechanisms regulating gene expression and can improve the detection of vulnerable individuals to the effects of early adversity exposure. This chapter revisits the concept of functional genomics and explores innovative techniques across different levels of gene regulation. The application of these functional genomics tools to improve polygenic risk score predictions and detect gene-environment interactions in the psychiatric field is discussed.