Alzheimer’s disease (AD) is a neurodegenerative disorder marked by the buildup of amyloid-beta plaques, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Epigenetics influences numerous complications at the cellular and molecular levels, including metabolic and cardiovascular complications, including cancer, and neurological and neurodegenerative disorders such as AD. Epigenetic mechanisms encompass histone modifications, DNA methylation, and noncoding RNAs, which have a significant impact on AD progression and pathways. In AD, the epigenetic mechanism is deregulated and is characterized by a general repressed chromatin state that alters gene expression at the transcriptional level through DNA hypermethylation, deacetylation of histones, and downregulation or silencing of genes. Therefore, these epigenetic processes have shown great potential as a therapeutic target in AD. In this chapter, epigenetic processes effective in AD will be discussed.