Acne, a chronic and recurrent inflammatory disease of the pilosebaceous unit, is particularly prevalent during adolescence and is the most common dermatological concern during this developmental stage. Adolescence is a crucial period for identity development, and diseases primarily or predominantly affecting the face may have significant psychosocial implications, especially among adolescents. Various methods such as loosely structured interviews and validated questionnaires have been used to assess self-esteem in adolescent acne patients, revealing a notable prevalence of low self-esteem within this group, particularly among females. Subjective perceptions of acne severity tend to have a more profound impact on self-esteem than objective measures. Additionally, factors such as age at onset of the disease, presence of post-acne scarring, and concurrent mental health problems like depression, anxiety, and body dysmorphic disorder may further affect self-esteem in acne patients. Studies have also demonstrated a positive correlation between self-esteem and quality of life among adolescent acne patients. A holistic approach to patient care, addressing both the physical and emotional dimensions of acne, is essential for promoting overall well-being.