Previous research supports the association between mental health and atopic dermatitis (AD), including the correlation between psychological stress and AD severity. The impact of AD on mental health is mainly related to AD’s long-lasting effects. Stress can both trigger and result from AD, and chronic stress in genetically predisposed individuals may contribute to AD onset and impair therapeutic control. Specifically, chronic stress promotes the release of glucocorticoids, which stimulate T-helper type 2 (Th2) responses while suppressing T-helper type 1 (Th1) responses, favoring atopic conditions. Thus, psychological stress can directly influence the skin’s epidermal barrier, subsequently affecting a patient’s condition. Literature data suggests stress and stressful events may significantly exacerbate the severity of AD symptoms. However, there is still limited research providing objective and reliable indicators that confirm this correlation. This chapter also presents key data on the influence of stress on AD patients’ behavior and psychology.