This chapter explores the vital role that social support plays in the management of hepatitis C, a major global public health issue. It begins by tracing the evolution of hepatitis C, from its discovery as a viral infection primarily affecting the liver to the development of direct-acting antiviral (DAA) drugs that have revolutionized treatment options. The chapter highlights the diverse range of social support that comes from different social networks, including emotional, practical, informational, and assessment assistance. It investigates the impact of social support on treatment adherence, healthcare utilization, and clinical outcomes among people living with hepatitis C, drawing on empirical data and theoretical frameworks. The chapter also highlights gaps in practice and research and examines methods to increase social support. It offers practical advice for healthcare professionals, legislators, and future research initiatives by emphasizing the critical role that social support plays in hepatitis C management.