Recent advancements in generative artificial intelligence have provided unique opportunities for seamless information access and discovery, particularly through natural language interactions. These technologies enable users to easily describe their needs and provide interactive feedback. This chapter provides an overview of the opportunities and challenges in interacting with information access systems powered by generative artificial intelligence technologies. We focus on user interfaces in these systems and various interactions for describing and clarifying users’ needs, refining the result list produced by the system, providing proactive feedback to the system, the system proactively initiating conversations, explaining the result list, and enabling multi-modal interactions for information access.