Pretrained Deep Neural Networks (DNNs), developed from extensive datasets to integrate multifaceted knowledge, are increasingly recognized as valuable intellectual property (IP). To safeguard these models against IP infringement, strategies for ownership verification and usage authorization have emerged. Unlike most existing IP protection strategies that concentrate on restricting direct access to the model, our study addresses an extended DNN IP issue: applicability authorization, aiming to prevent the misuse of learned knowledge, particularly in unauthorized transfer learning scenarios. We propose Non-Transferable Pruning (NTP), a novel IP protection method that leverages model pruning to control a pretrained DNN’s transferability to unauthorized data domains. Selective pruning can deliberately diminish a model’s suitability on unauthorized domains, even with full fine-tuning. Specifically, our framework employs the alternating direction method of multipliers (ADMM) for optimizing both the model sparsity and an innovative non-transferable learning loss, augmented with fisher space discriminative regularization, to constrain the model’s generalizability to the target dataset. We also propose a novel effective metric to measure the model non-transferability: Area Under the Sample-wise Learning Curve (SLC-AUC). This metric facilitates consideration of full fine-tuning across various sample sizes. Experimental results demonstrate that NTP significantly surpasses the state-of-the-art non-transferable learning methods, with an average SLC-AUC at −0.54 across diverse pairs of source and target domains, indicating that models trained with NTP do not suit for transfer learning to unauthorized target domains. The efficacy of NTP is validated in both supervised and self-supervised learning contexts, confirming its applicability in real-world scenarios. Git Repo