This chapter focuses on the translation of a crucial theme in US underground comix, i.e., drug ‘culture’. In a similar way to what was contended in the case of sexuality, underground authors’ relationship with drugs was much more complex than what the slogan ‘sex, drugs, rock’n’roll’ may suggest (Miller in The Hippies and American Values, The University of Tennessee Press, Knoxville, 2011[1991]; Stevens in Storming Heaven: LSD and the American Dream, Paladin, London, 1989). For some authors, drugs were a device to shock bourgeois readers, for others, drug-taking was perceived as expanding the mind. Hard drugs, however, were overall harshly criticised and depicted as a social issue. In general, drugs were merely a part of the authors’ own daily lives used to respond to moralism and censorship. By analysing a set of examples from Crumb, Shelton, Greg Irons, and Tom Veitch, this chapter discusses how the Italian translations re-interpreted this theme, by focusing on visual and verbal changes and additions designed to adapt the source material to the target tastes and expectations. Italian translations by mainstream publishers overlooked the representation of actual drug use in the ST and adopted trivial hermeneutic frames. Additions were made to emphasise a light-hearted and hedonistic dimension of drug use. By contrast, militant translations used addition as a strategy aimed at increasing the ‘shock value’, while at the same time comparing the US and the Italian countercultural experiences based on a perceived shared knowledge of drug culture. In this latter case, however, a lack of expertise on the part of the translators actually caused a stylistic and linguistic loss, e.g., in terms of drugs jargon. Findings show that stereotypes and bias regarding drugs influenced the translation process, regardless of the actual source message.