Remote work is commonplace nowadays, with software startups actively embracing it. However, remote work poses various challenges, among which team challenges are prominent and highly relevant to early-stage software startups, since effective team collaboration is one key factor for them to operate and succeed in uncertain environments. Challenges faced by early-stage software startup teams are less explored, especially in remote work settings. This research will propose a design framework to address the challenges faced by early-stage software startup teams in remote work settings. This research uses multi-case study to facilitate a deeper understanding of the phenomenon. Expected significance of findings lies in the identification of unique challenges and key practices to tackle those challenges, offering actionable insights and innovative solutions.