Over the last four decades, Ethiopia has been involved in massive road constructions which pass through complex geological, geotechnical, hydrological and terrain conditions of the country. The sustainability and functionality of these roads is, however, hugely affected by interrelated geohazards. This paper presents on the characteristics of landslides that have been affecting road networks in Ethiopia with data from research, practice and documentation over 25 years period (1997–2022). The study involved: (1) field inventory and characterization of 158 landslide-affected road sections, (2) investigations of the geological, geohydrological and geotechnical conditions, (3) monitoring groundwater levels and spring discharges, (4) measurement of flood levels of rivers/streams close to landslides, (5) in-situ and laboratory tests of the engineering properties of soils and rocks, (6) assessments on the association of the landslides with gully erosion, construction, and other factors, and (7) assessments on the performances of mitigation measures implemented. Results revealed that debris/earth slides are the dominant types of failures, with some debris/earth flows. Failures occurred in unconsolidated sediments with certain conditions: (a) concave terrains with slope angles 12°–38°, (b) variable depths of failures: maximum values 2.5–13.5 m, (c) shallow groundwater systems: water level fluctuated between 0 and 3.5 m below surface, and (d) active stream/river incisions at downslope sides of the roads. Broadly, the landslide-road-landscape interactions could be categorized into three: (a) failure of the upslope part of the road, (b) failure of the downslope part of the road, and (c) failure of the whole road section (upslope, road and downslope). Though different mitigation measures were implemented in 125 sites, the measures were unsuccessful in 70 sites (56%). In all the landslide-affected road sections, no comprehensive geological/geotechnical site investigations and slope stability analysis were carried out and the landslide-road-landscape interactions were poorly understood. With the expected increase in road/railway network development, limited capacity, climate change and fragile nature of the Ethiopian landscapes, landslides and associated problems are expected to pose major risks unless due attention is given to these interrelated geohazards. This calls for further collaborative research, innovations, and capacity building to address landslides and related geohazards in Ethiopia and in other developing countries with similar conditions.