Drug Delivery Systems Meeting Quality and Safety Requirements

The goal of any drug delivery system is to provide and maintain a therapeutic concentration of the drug in the pathological focus of the animal's body over a long period of time. Incomplete drug delivery systems release and shorter residence times in the body result in decreased bioavailability. Efforts to improve bioavailability are being undertaken in parallel with the development of the pharmaceutical industry. As the number and chemical diversity of drugs increases, new strategies for delivering active substances are emerging. The transformation and elimination of drugs depends not only on the characteristics of nanoparticles and the physiological functions of the body, but also on the route of administration, which is established during the development of a new dosage form. Thus, to improve the bioavailability of nanoparticles in animals and enhance the efficacy of the drug delivered, careful design of engineered particles for a specific route of administration is required. Such a design must account for in vivo transformations that may alter the activity and distribution of the drug, and must minimize the release into the environment and negative consequences to animal, humans, and the environment.