Following the current stage of social and economic development, the construction industry has also increased certain progress, and construction safety management is very important in the construction of construction projects. When they compare with the classical construction safety management, it is possible for BIM technology to discover the latent dangers in the construction project and check the potential safety hazards in time, so as to ensure the security of the construction. To this end, first of all, this paper analyzes the main risk elements and problems that exist in engineering security management, and then investigates the advantages of BIM technology application on construction security analysis. Secondly, based on an entropy weight method and combining the construction characteristics of construction projects, this paper screens and analyzes five key factors, such as personnel factors, material factors, environmental factors, equipment factors and management factors, and constructs a risk management index system of information technology safety management of construction projects based on computer BIM technology, and introduces the entropy weight method into the evaluation of the risk of safety management. Finally, its evaluation outcomes are as follows: Table 5 shows that the weights of the first-level indicators are arranged in the following order from the largest to the smallest: equipment factors (0.2882) > management factors (0.2294) > personnel factors (0.1852) > material factors (0.1772) > environmental factors (0.1200); among the 17 s-level indicators, the four indicators whose weights are ranked in the top of the list are the safety and security measures, on-site safety management system, deep foundation pit and support equipment management, and construction workers’ safety education and training. This study not only provides a scientific theoretical structure for the safety of construction project management, but also clarifies various risk factors’ weights through specific data analysis, which provides a powerful data support for safety management decision-making in engineering practice. The application of informationized safety management based on bioinformatics (BIM) technology does to improve not only the efficiency as well as the accuracy in safety management of construction projects, but also provides a new direction and idea for the research and practice of safety management in future projects.