Organizations have been increasingly dealing with scenarios of great competitiveness and uncertainty to guide their planning, but also composed of many investment opportunities. Strategic, organizational, and technological prospective methodologies support decision-making in this complex context in which organizations operate and technologies are developed, assisting them with current actions and future objectives. Technology roadmapping is a tool to connect technologies, products, services, and markets throughout the technology lifecycle. The purpose of this paper is to demonstrate a technology roadmapping through a case study on the development of a nuclear technology that addresses the circular economy and a successful innovation, focusing on mapping essential competencies (knowledge, skills and attitudes) and resources (finance, partnership and infrastructure); and recognizing the challenges and opportunities inherent to a diverse and balanced team building and stakeholders’ engagement in partnerships with a public research organization. The relevance of this paper can be highlighted from the perspective of a R&D project centered on the deployment of new nuclear technology fostering the development of key personnel, creating value, and aligning with global tendencies on science, technology, innovation, and sustainability.